For a video game, sure, they can add fuel lines or multiple fuel transfers at once, make flights more fuel efficient.
In real life? You'd run into many fluid dynamic and mechanical issues, say for a booster fuel transfer to core, you'd have to work with transferring fluids between areas of possibly varying pressures, and then there's staging, making sure the port seals properly after separation would be a challenge. Last thing you want is a propellant leak.
Chelomy planned to use asparagus staging for his UR-700 lunar direct launch vehicle, but he never got to construct it. Furthest he got was building the RD-270 engine tailored specially for the UR-700, designed and built by Glushko. Till this day, it might be the most powerful hypergolic single chamber rocket engine to date.